CB2 cannabinoid receptor agonist, JWH-015, triggers apoptosis in immune cells: potential role for CB2-selective ligands as immunosuppressive agents.

https://www.ncbi.nlm.nih.gov/pubmed/17185040 Cannabinoids are known to interact with CB1 and CB2 receptors expressed in the nervous and immune system, respectively, and mediate a wide range of effects, including anti-inflammatory properties. However, cannabinoids that bind CB1 are also psychoactive thereby limiting their clinical use. In this study, we investigated the immunosuppressive properties of JWH-015, a synthetic CB2-selective…

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Viewing addiction as a brain disease promotes social injustice

The view of drug use and drug addiction as a brain disease serves to perpetuate unrealistic, costly, and discriminatory drug policies, argues Carl L. Hart. “More than 25 years ago, I began studying neuroscience because I thought this approach would uniquely fix the ‘drug problem’. At that time, I believed that the poverty and crime…

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