Pain Management

Human Cannabinoid Pharmacokinetics

A multitude of roles for the endogenous cannabinoid system has been proposed by recent research efforts. A large number of endogenous cannabinoid neurotransmitters or endocannabinoids have been identified, and the CB-1 and CB-2 cannabinoid receptors have been characterized. The presence of other receptors, transporters, and enzymes responsible for the synthesis or metabolism of endocannabinoids are […]

ABSTRACT:Background We consider how many cannabis users may need to be prevented in order to prevent one case ofschizophrenia or psychosis [defined as number needed to prevent (NNP)]. Method Calculation for England and Walesusing best available estimates of: incidence of schizophrenia; rates of heavy and light cannabis use; and risk thatcannabis causes schizophrenia. Results In […]

Doctors with the U.S. Department of Veterans Affairs still can’t recommend medical marijuana, but they are being encouraged to talk more about it with military veterans. V.A. Issues New Medical Marijuana Policy For Military Veterans Veterans groups react to VA’s shift in medical marijuana policy Congressional members press VA chief to help vet-focused marijuana research […]

CB2 cannabinoid receptor agonist, JWH-015, triggers apoptosis in immune cells: potential role for CB2-selective ligands as immunosuppressive agents. Cannabinoids are known to interact with CB1 and CB2 receptors expressed in the nervous and immune system, respectively, and mediate a wide range of effects, including anti-inflammatory properties. However, cannabinoids that bind CB1 are also psychoactive thereby limiting their clinical use. In this study, we investigated the immunosuppressive properties of JWH-015, a synthetic CB2-selective […]